Lexapro is a prescription medication used to treat depression, major depressive disorder (MDD), and generalized anxiety disorder (GAD). Lexapro may increase suicidal thoughts or actions in some children, teenagers, or young adults in the first few months of treatment or when the dosage is changed.
“Serotonin Syndrome and MAOIs: Do not use MAOIs intended to treat psychiatric disorders with Lexapro or within 14 days of stopping treatment with Lexapro. Do not use Lexapro within 14 days of stopping an MAOI intended to treat psychiatric disorders. In addition, do not start Lexapro in a patient who is being treated with linezolid or intravenous methylene blue (4.1).
Pimozide: Do not use concomitantly (4.2).
Known hypersensitivity to escitalopram or citalopram or any of the inactive ingredients (4.3).”
LEXAPRO WARNINGS AND PRECAUTIONS
“Clinical Worsening/Suicide Risk: Monitor for clinical worsening, suicidality and unusual change in behavior, especially, during the initial few months of therapy or at times of dose changes (5.1).
Serotonin Syndrome: Serotonin syndrome has been reported with SSRIs and SNRIs, including Lexapro, both when taken alone, but especially when co-administered with other serotonergic agents (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone and St. John’s Wort). If such symptoms occur, discontinue Lexapro and initiate supportive treatment. If concomitant use of Lexapro with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for
serotonin syndrome, particularly during treatment initiation and dose increases (5.2).
Discontinuation of Treatment with Lexapro: A gradual reduction in dose rather than abrupt cessation is recommended whenever possible (5.3).
Seizures: Prescribe with care in patients with a history of seizure (5.4).
Activation of Mania/Hypomania: Use cautiously in patients with a history of mania (5.5).
Hyponatremia: Can occur in association with SIADH (5.6).
Abnormal Bleeding: Use caution in concomitant use with NSAIDs, aspirin, warfarin or other drugs that affect coagulation (5.7).
Interference with Cognitive and Motor Performance: Use caution when operating machinery (5.8).
Use in Patients with Concomitant Illness: Use caution in patients with diseases or conditions that produce altered metabolism or hemodynamic responses (5.9).”
LEXAPRO ADVERSE REACTIONS
“Most commonly observed adverse reactions (incidence ≥ 5% and at least twice the incidence of placebo patients) are: insomnia, ejaculation disorder (primarily ejaculatory delay), nausea, sweating increased, fatigue and somnolence, decreased libido, and anorgasmia (6.1).”
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