Even though Celexa is an SSRI, it has a chemical structure that is unrelated to other SSRI’s. Celexa is a “Racemic Bicyclic Phthalane Derivative.”
Celexa’s Box Warning:
Suicidality and Antidepressant Drugs
“Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of Celexa or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Celexa is not approved for use in
pediatric patients. (See WARNINGS: Clinical Worsening and Suicide Risk,
PRECAUTIONS: Information for Patients, and PRECAUTIONS: Pediatric Use.)”
Celexa side effects can include, but are not limited to:
- Abnormal Bleeding – SSRI’s including Celexa may increase the risk of bleeding events.
- Clinical Worsening and Suicide Risk – Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability,, hostility, aggressiveness, impulsivity, akathisia, hypomania, mania, worsening of depression, and suicidal ideation.
- Activation of Mania/Hypomania – Celexa should be used cautiously in patients with a history of mania
- Seizures – In clinical trials of Celexa, seizures occurrred in 0.3% of patients treated with Celexa
- Interference with Cognitive and Motor Performance – Psychoactive drugs like Celexa may impair judgement, thinking, or motor skills.
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