There is a risk of heart rhythm abnormalities when taking Celexa (Citalopram HBr)
Celexa is an SSRI (Selective Serotonin Reuptake Inhibitor) approved by the FDA (Food and Drug Administration) in July of 1998 to treat major depression.
In 2011, the FDA publicized “Celexa should no longer be administered at doses greater than 40 mg per day, due to a risk of abnormal electrical activity in the heart, which may lead to potentially fatal heart rhythm abnormalities.” Initially, Celexa’s drug label stated that certain patients may require a dose of 60 mg per day. This is no longer the case.
Additionally, there is controversy over some publishing of SSRI clinical trials. Combined results from different studies of published, as well as unpublished trials find placebos to be similarly effective to SSRI’s.
Side effects of Celexa may include:
Abnormal Bleeding – SSRI’s including Celexa may increase the risk of bleeding events.
Clinical Worsening and Suicide Risk – Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, mania, worsening of depression, and suicidal ideation.
Activation of Mania/Hypomania – Celexa should be used cautiously in patients with a history of mania
Seizures – In clinical trials of Celexa, seizures occurred in 0.3% of patients treated with Celexa
Interference with Cognitive and Motor Performance – Psychoactive drugs like Celexa may impair judgement, thinking, or motor skills.
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